Endocytic uptake and vesicular transport of injected horseradish peroxidase in the vacuolar apparatus of rat liver cells |
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| Authors: | J Creemers P J Jacques |
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| Affiliation: | 1. Laboratorium voor Elektronenmicroscopie, Vesalius Instituut, Katholieke Universiteit te Leuven, Belgium;2. Laboratoire de Chimie Physiologique, Université de Louvain, Belgium;3. Centre de Recherches Biologiques, Université de Bujumbura, Burundi;1. School of Chemistry and Chemical Engineering, University of Jinan, Jinan, Shandong 250022, China;2. Department of Chemistry and Nanoscience, Ewha Womans University, Seoul 03760, South Korea;1. School of Water Conservancy and Environment, University of Jinan, Jinan, 250022, China;2. College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Institutes of Biomedical Sciences, Shandong Normal University, Jinan, 250014, China;3. College of Medicine, Linyi University, Linyi, 276005, China;1. Biology Institute, Bioengineering Department, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250103, China;2. School of Water Conservancy and Environment, University of Jinan, Jinan 250022, China |
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| Abstract: | Horseradish peroxidase (HRP) has been used as a cytochemical tracer to study peculiar ultra-structural aspects of exogenous protein uptake and fate in four types of rat liver cells.In all cell types HRP was adsorbed on the cell surface prior to endocytotic engulfment and sequestration within cytoplasmic particles.Most often, the pinocytotic vesicles ultimately acquired acid phosphatase activity thus becoming digestive vacuoles. In hepatocytes however, many of them seemed involved in diacytosis towards the bile canaliculi.The localization of HRP in cytoplasmic annular profiles and intercellular spaces is also described. |
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