The molecular basis of P-M hybrid dysgenesis: The role of the P element,a P-strain-specific transposon family |
| |
Authors: | Paul M Bingham Margaret G Kidwell Gerald M Rubin |
| |
Institution: | Laboratory of Genetics National Institute of Environmental Health Sciences Research Triangle Park, North Carolina 27709 USA;Division of Biology and Medicine Brown University Providence, Rhode Island 02912 USA;Department of Embryology Carnegie Institution of Washington 115 West University Parkway Baltimore, Maryland 21210 USA |
| |
Abstract: | We have shown previously that four of five white mutant alleles arising in P-M dysgenic hybrids result from the insertion of strongly homologous DNA sequence elements. We have named these P elements. We report that P elements are present in 30–50 copies per haploid genome in all P strains examined and apparently are missing entirely from all M strains examined, with one exception. Furthermore, members of the P family apparently transpose frequently in P-M dysgenic hybrids; chromosomes descendant from P-M dysgenic hybrids frequently show newly acquired P elements. Finally, the strain-specific breakpoint hotspots for the rearrangement of the π2 P X chromsome occurring in P-M dysgenic hybrids are apparently sites of residence of P elements. These observations strongly support the P factor hypothesis for the mechanistic basis of P-M hybrid dysgenesis. |
| |
Keywords: | |
本文献已被 ScienceDirect 等数据库收录! |