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VIP (Vasoactive Intestinal Polypeptide) — immunoreactive innervation of the portal vein
Authors:J Järhult  J Fahrenkrug  P Hellstrand  R Uddman
Institution:(1) Department of Physiology, University of Lund, Lund, Sweden;(2) Department of Histology, University of Lund, Lund, Sweden;(3) Department of Clinical Chemistry, Bispebjerg Hospital, Copenhagen, Denmark;(4) Dept. of physiology, solvegatan 19, s-22362 lund, Sweden
Abstract:Summary Nerve fibres displaying immunoreactivity for vasoactive intestinal polypeptide (VIP) were found in the wall of the portal vein in cats, guinea pigs, rats and mice. In whole-mount preparations a sparse network of VIP fibres was seen in the vessel wall. Electrical field stimulation of the rat portal vein in vitro caused a significant release of VIP. The results suggest that VIP ergic nerve fibres play a role in the regulation of portal blood flow.
Keywords:Vasoactive intestinal polypeptide (VIP)  Peptidergic nerves  Portalvein  Vascular effects
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