Aqua mediated synthesis of substituted 2-amino-4H-chromenes and in vitro study as antibacterial agents |
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Authors: | Kidwai Mazaahir Saxena Shilpi Khan M Khalilur Rahman Thukral Sharanjit S |
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Institution: | Department of Chemistry, University of Delhi, Delhi 110007, India. kidwai_chemistry@yahoo.co.uk |
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Abstract: | A simple, clean, environmentally benign route to the synthesis of 2-amino-chromenes is described using K2CO3 as a green catalyst in water under microwave irradiation. This implies a convenient route avoiding the usage of hazardous organic solvents and organic bases. This technique requires only water in both the reaction step and workup, thus rendering the whole procedure into a truly ecofriendly green protocol. All the synthesized compounds were shown to possess antibacterial activity as tested in vitro against standard strains of Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus. |
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