Nogo-A expressed in Schwann cells impairs axonal regeneration after peripheral nerve injury |
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Authors: | Pot Caroline Simonen Marjo Weinmann Oliver Schnell Lisa Christ Franziska Stoeckle Sascha Berger Philipp Rülicke Thomas Suter Ueli Schwab Martin E |
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Institution: | Brain Research Institute, University of Zurich, and Department of Biology, Swiss Federal Institute of Technology Zurich, CH-8057 Zurich, Switzerland. caroline.pot@access.unizh.ch |
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Abstract: | Injured axons in mammalian peripheral nerves often regenerate successfully over long distances, in contrast to axons in the brain and spinal cord (CNS). Neurite growth-inhibitory proteins, including the recently cloned membrane protein Nogo-A, are enriched in the CNS, in particular in myelin. Nogo-A is not detectable in peripheral nerve myelin. Using regulated transgenic expression of Nogo-A in peripheral nerve Schwann cells, we show that axonal regeneration and functional recovery are impaired after a sciatic nerve crush. Nogo-A thus overrides the growth-permissive and -promoting effects of the lesioned peripheral nerve, demonstrating its in vivo potency as an inhibitor of axonal regeneration. |
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Keywords: | Nogo-A growth-inhibitory protein regeneration peripheral nervous system axonal repair |
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