Optimization of TCR transgenic T cells for in vivo tracking of immune responses |
| |
Authors: | Stock Angus T Mueller Scott N Kleinert Lauren M Heath William R Carbone Francis R Jones Claerwen M |
| |
Institution: | Department of Microbiology and Immunology, The University of Melbourne, Parkville, Victoria, Australia. |
| |
Abstract: | T-cell receptor (TCR) transgenic mice have proven useful for the study of various immune parameters. Despite this, it has been suggested that transferred T cells respond differently to their endogenous counterparts at least in terms of conversion to antigen-experienced populations bearing memory cell markers. Here, we have compared the response of TCR transgenic T cells to endogenous populations within the context of infection with herpes simplex virus. We found that adoptive transfer at numbers approaching those of the endogenous virus-specific subset results in a response with similar kinetics, magnitude and memory subset conversion. This suggests that this form of optimized T-cell transfer remains a useful means of tracking antiviral immune responses. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|