Lipid Dynamics in Exocytosis |
| |
| Authors: | S Chasserot-Golaz J R Coorssen F A Meunier N Vitale |
| |
| Institution: | 1.Département Neurotransmission & Sécrétion Neuroendocrine, Institut des Neurosciences Cellulaires et Intégratives (UPR-3212), Centre National de la Recherche Scientifique,Université de Strasbourg,Strasbourg,France;2.Department of Molecular Physiology, School of Medicine and Molecular Medicine Research Group and Nanoscale Organization and Dynamics Group,University of Western Sydney,Penrith South DC,Australia;3.Neuronal Trafficking Laboratory, Queensland Brain Institute,University of Queensland,Brisbane,Australia |
| |
| Abstract: | Regulated exocytosis of neurotransmitter- and hormone-containing vesicles underpins neuronal and hormonal communication and
relies on a well-orchestrated series of molecular interactions. This in part involves the upstream formation of a complex
of SNAREs and associated proteins leading to the eventual fusion of the vesicle membrane with the plasma membrane, a process
that enables content release. Although the role of lipids in exocytosis is intuitive, it has long been overlooked at least
compared to the extensive work on SNAREs. Here, we will present the latest advances in this rapidly developing field revealing
that lipids actually play an active role in exocytosis by focusing on cholesterol, 3′-phosphorylated phosphoinositides and
phosphatidic acid. |
| |
| Keywords: | |
| 本文献已被 PubMed SpringerLink 等数据库收录！ |
|
