真菌性食管炎患者抗真菌治疗期间血常规、免疫功能动态变化的特征分析

目的分析真菌性食管炎患者接受抗真菌治疗期间血常规及免疫功能动态变化的特征。方法将我院收治的42例真菌性食管炎患者纳入实验组,给予患者氟康唑联合克霉唑抗真菌治疗;同期收治的42例反流性食管炎纳入对照组,给予常规治疗。两组分别于入院时、治疗1 d、3 d、5 d、7 d及14 d,动态开展血常规检查及免疫功能指标监测。治疗过程中,观察两组不良反应。结果治疗期间,实验组白细胞计数呈下降趋势,中性粒细胞百分比则呈上升趋势;对照组白细胞计数呈下降趋势,中性粒细胞无明显变化。治疗1 d、3 d、5 d、7 d、14 d,组间白细胞计数差异显著(P<0.05);入院时、治疗1 d、3 d、5 d、7 d,组间中性粒细胞对比差异显著(P<0.05),治疗14 d,组间中性粒细胞百分比差异不显著(P>0.05)。实验组、对照组CRP均呈下降趋势,治疗1 d、3 d、5 d、7 d、14 d CRP水平组间对比差异有统计学意义(P<0.05);实验组、对照组食管炎患者IgM及IgG均呈升高趋势,治疗1 d、3 d、5 d、7 d、14 d对比,两组差异均具有统计学意义(P<0.05)。结论真菌性食管炎患者多伴明显免疫功能下降、中性粒细胞比例降低。治疗期间,血常规检查、免疫功能的动态监测可为真菌性食管炎患者的疗效评估提供临床依据。

Dynamic changes of blood routine and immune function in patients with fungal esophagitis during antifungal therapy

Objective To analyze the dynamic changes of blood routine and immune function in patients with fungal esophagitis.Methods Fourty-two cases of mycotic esophagitis in our hospital were included in the experimental group,and the patients were given fluconazole and clotrimazole antifungal treatment;42 cases of reflux esophagitis in the same period were included in the control group,and given routine treatment.Blood routine examination and immune function monitoring were carried out dynamically in the two groups at the time of admission,1,3,5,7 and 14 days after treatment.During the treatment,adverse reactions were observed.Results During the treatment,the white blood cell count in the experimental group showed a downward trend,while the percentage of neutrophils showed an upward trend;in the control group,the white blood cell count showed a downward trend,and there were no significant changes in the neutrophil count.There were significant differences in WBC count among the groups on 1 d,3 d,5 d,7 d,14 d after treatment(P<0.05);on admission,on 1 d,3 d,5 d,7 d,the neutrophil comparison between the groups was significant(P<0.05),while on the 14th day of treatment,there were no significant differences in the percentage of neutrophils among the groups(P>0.05).CRP levels in the experimental group and the control group showed a downward trend,and there were significant differences between the two groups on the 1st,3rd,5th,7th and 14th days of treatment(P<0.05);the IgM and IgG of the experimental group and the control group were increased,and the differences between the two groups were statistically significant(P<0.05).Conclusions Most of the patients with fungal esophagitis had decreased immune function and neutrophil ratio.During the treatment,routine blood test and dynamic monitoring of immune function could provide clinical basis for curative effect evaluation of patients with fungal esophagitis.