| 大鼠胼胝体内神经肽Y免疫反应阳性纤维的发育 |
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| 引用本文： | 丁松林,郑德枢. 大鼠胼胝体内神经肽Y免疫反应阳性纤维的发育[J]. 中国组织化学与细胞化学杂志, 1996, 0(1) |
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| 作者姓名： | 丁松林 郑德枢 |
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| 作者单位： | 广州医学院神经科学研究所，美国田纳西大学神经科学中心 |
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| 摘 要： | 本实验用免疫组织化学ＡＢＣ法研究了大鼠胼胝体内神经肽Ｙ免疫反应阳性（ＮＰＹ－ＩＲ）纤维的生后发育。结果发现，许多ＮＰＹ－ＩＲ纤维在大鼠出生时便存在于胼胝体内。ＮＰＹ－ＩＲ胼胝体纤维的密度在生后１周内继续逐渐增高，在第２周内达到最高峰。之后，ＮＰＹ－ＩＲ胼胝体纤维的密度逐渐下降，至第３周末时接近成年时的水平，即仅有少量ＮＰＹ－ＩＲ纤维存在于胼胝体内。这些结果提示在大鼠早期生后发育过程中许多ＮＰＹ－ＩＲ胼胝体纤维是暂时性的，其作用可能与大脑皮质的机能发育有关。
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| 关 键 词： | 胼胝体，神经肽Y，免疫组织化学，发育，大鼠 |
DEVELOPMENT OF NEUROPEPTIDE Y IMMUNOREACTIVE FIBERS IN THE CORPUS CALLOSUM OF THE RAT |
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| Ding Songlin, Elberger AJ, Zheng Deshu. DEVELOPMENT OF NEUROPEPTIDE Y IMMUNOREACTIVE FIBERS IN THE CORPUS CALLOSUM OF THE RAT[J]. Chinese Journal of Histochemistry and Cytochemistry, 1996, 0(1) |
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| Authors: | Ding Songlin Elberger AJ Zheng Deshu |
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| Abstract: | Postnatal development of neuropeptide Y--immunoreactive (NPY--IR) fibers in rat corpuscallosum was investigated by means of immunohistochemistry (ABC method). It was foundthat many NPY--IR callosal fibers had appeared in the corpus callosum of the newborn rat.The density of NPY--IR callosal fibers increased during postnatal week (PNW) 1 and peakedin PNW 2. Thereafter,' the density of NPY--IR callosal fibers decreased, and became close tothe adult level by the end of PNW 3. In the adult, only a few NPY--IR fibers were seen in thecorpus callosum.- These results indicate that many NPY--IR callosal fibers during postnataldevelopment are transient and these transient callosal fibers may play a role in the functionaldevelopment of the cerebral cortex. |
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| Keywords: | Corpus callosum Neuropeptide Y Immunohistochemistry Development Rat |
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