Resistance to (L)-azetidin-2-carboxylic acid in Bacillus subtilis. |
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Authors: | E Gallori M Bazzicalupo B Parisi G Pedaggi M Polsinelli |
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Institution: | 1. Istituto di Anatomia Comparata, Biologia Generale e Genetica, Università di Firenze, Italy;1. Istituto di Microbiologia e Fisiologia Vegetale, Università di Pavia, Italy |
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Abstract: | A spontaneous mutant of resistant to (L)-azetidin-2-carboxylic acid, a structural analogue of (L)-proline, has been isolated and characterized. Data have been obtained which indicate that binding of 14C]-proline to tRNAs from the resistant strain is reduced only in part by (L)-azetidin-2-carboxylic acid, while a complete inhibition of binding occurs using tRNAs from parental strain. The mutation conferring resistance to the analogue and a mutation for proline auxotrophy have been mapped. |
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Keywords: | AZC (L)-azetidin-2-carboxylic acid resistance to (L)-azetidin-2-carboxylic acid |
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