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Effect of ubiquinone-homologs on the sensitivity of mitochondrial ATPase to energy transfer inhibitors. |
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| Authors: | G Parenti-Castelli M Degli Esposti E Bertoli G Lenaz |
| Abstract: | Short-chain ubiquinone (UQ-3) abolishes oligomycin sensitivity of ATPase in submitochondrial particles and the effect is reversed by long-chain ubiquinone (UQ-7). Ubiquinone-3 also abolishes DCCD sensitivity of ATPase in submitochondrial particles but the effect is not reversed by long-chain ubiquinones. These data suggest that ubiquinone interferes with energy transfer process by interaction with mitochondrial ATPase. |
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