Differential expression and extent of fungal/plant and fungal/bacterial chitinases of <Emphasis Type="Italic">Aspergillus fumigatus</Emphasis> |
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Authors: | Mariam?Taib John?W?Pinney David?R?Westhead Kenneth?J?McDowall Email author" target="_blank">David?J?AdamsEmail author |
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Institution: | (1) School of Biochemistry & Microbiology, University of Leeds, LS2 9JT Leeds, UK;(2) School of Biology, University of Leeds, LS2 9JT Leeds, UK |
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Abstract: | We provide the first indication of the extent of the complex chitinolytic system of a filamentous fungus. Phylogenetic analysis
of the 14 apparent chitinases of the opportunistic fungal pathogen Aspergillus fumigatus identified four and ten enzymes related to plant and bacterial chitinases, respectively. Further, real time-RT-PCR studies
revealed distinct patterns of gene expression, consistent with morphogenetic or nutritional roles, for members of the fungal/plant
or fungal/bacterial sub-families, respectively. Our results provide a basis for future studies with A. fumigatus chitinases, which may lead to the exploitation of these enzymes, or their regulators, in the development of novel drug strategies. |
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