妊娠期糖尿病血清和脂肪组织内脂素的表达

目的:探讨妊娠期糖尿病孕妇内脂素水平与糖代谢的关系.方法:检测血清中内脂素、FIN、FIG水平,计算HOMA-IR,用RT-PCR法检测脂肪组织中内脂素mRNA的表达.结果:(1)妊娠期糖尿病组孕妇血清内脂素、FPG、HOMA-IR、FIN明显高于对照组.(2)妊娠期糖尿病组孕妇内脏脂肪组织中的内脂素的表达明显高于对照组,且妊娠期糖尿病组孕妇内脏组织中内脂素的表达明显高于表皮脂肪组织.(3)血清中内脂素的水平与内脏脂肪组织及HOMA-IR呈正相关.结论:妊娠期糖尿病孕妇脂肪组织中内脂素表达上调,导致血液循环中内脂素水平升高,参与GDM孕妇血糖调节.

Expression of Visfatin in Serum and Adipose Tissue in Gestational Diabetes Mellitus

Objective:To investigate the relationship between visfatin levels and glycometabolism in gestational diabetes mellitus (GDM).Method:The serum visfatin,fast insulin(FIN),Fast plasma glucose(FPG) were detected.Insulin resistance index (HOMA-IR) was calculated.The expression of visfatin mRNA in adipose was detected by RT-PCR.Results:(1)The serum levels of visfatin,FPG,HOMA-IR,FIN were significantly higher in GDM group than that in control group(P＜0.01).(2)The levels of visfatin mRNA in visceral adipose tissue (VAT) in GDM group were higher than that in the control group and the subcutaneus adipose tissue(SAT).(3)There were positive correlations between visfatin in surum and in visceral adipose tissue and HOMA-IR (P＜0.01).Conclusions:Increased serum levels of visfatin results in the overexpression of visceral adipose,which represents a compensatory mechanism aimed at high glucose levels in woman with GDM.