Demonstration of PGl2 production by isolated perfused rat lungs with platelet aggregation test |
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| Authors: | J Hartiala H Toivonen P Uotila |
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| Institution: | Department of Physiology University of Turku 20520 Turku 52 Finland |
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| Abstract: | Platelet aggregation test was used for PGl2 measurements. The use of 6 % CO2 in air stabilized human platelet rich plasma (PRP) so that it could be used for up to 7 hours in these measurements. The PGl2 caused inhibition of aggregation in response to ADP was concentration dependent in the range of 0.5 ng/ml to 50 ng/ml. Isolated perfused rat lungs released spontaneously 190 ng/min PGl2 and about 3 % of infused arachidonic acid potassium salt (equivalent to 25 μg/min arachidonic acid) was converted to PGl2. |
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