Equine CTNNB1 and PECAM1 nucleotide structure and expression analyses in an experimental model of normal and pathological wound repair |
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| Authors: | Vincenzo Miragliotta Zo? Ipi?a Josiane Lefebvre-Lavoie Jacques G Lussier and Christine L Theoret |
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| Institution: | (1) D?partement de biom?decine v?t?rinaire, Facult? de m?decine v?t?rinaire, Universit? de Montr?al, C.P. 5000, St-Hyacinthe, Qu?bec, J2S 7C6, Canada;(2) Department of veterinary anatomy, biochemistry and physiology, University of Pisa, Viale delle Piagge 2, 56100 Pisa, Italy |
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| Abstract: | Background Wound healing in horses is fraught with complications. Specifically, wounds on horse limbs often develop exuberant granulation
tissue which behaves clinically like a benign tumor and resembles the human keloid in that the evolving scar is trapped in
the proliferative phase of repair, leading to fibrosis. Clues gained from the study of over-scarring in horses should eventually
lead to new insights into how to prevent unwanted scar formation in humans. cDNA fragments corresponding to CTNNB1 (coding for β-catenin) and PECAM1, genes potentially contributing to the proliferative phase of repair, were previously identified in a mRNA expression study
as being up-regulated in 7 day wound biopsies from horses. The aim of the present study was to clone full-length equine CTNNB1 and PECAM1 cDNAs and to study the spatio-temporal expression of mRNAs and corresponding proteins during repair of body and limb wounds
in a horse model. |
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