Therapeutic effect of tyndallized Lactobacillus rhamnosus IDCC 3201 on atopic dermatitis mediated by down‐regulation of immunoglobulin E in NC/Nga mice |
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| Authors: | Seung‐Hun Lee Jong‐Min Yoon Young‐Hoo Kim Dong‐Gu Jeong Soobong Park Dae‐Jung Kang |
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| Institution: | 1. Research Laboratories, Ildong Pharmaceutical, Hwaseong 18449;2. Department of Biotechnology and Bioengineering, Konkuk University, 120, Neungdong‐ro, Gwangjin‐gu, Seoul 05029, Korea |
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| Abstract: | The therapeutic effect of oral administration of Lactobacillus rhamnosus IDCC 3201 tyndallizate (RHT3201) on atopic dermatitis (AD)‐like skin lesions in NC/Nga mice were investigated. After induction of dermatitis in NC/Nga mice with house‐dust mite extract, each group was fed RHT3201 with 1 × 108, 1 × 109, or 1 × 1010 cells orally once a day for 8 weeks. Dermatitis scores and frequency of scratching were improved by oral feeding with RHT3201. In contrast to the control group, RHT3201‐fed mice showed significantly down‐regulated mast cell numbers and serum immunoglobulin E (IgE) concentrations had significantly less IL4 in their axillary lymph node cells. The therapeutic effect of RHT3201 was found to be dose‐dependent. These findings indicate that RHT3201 has potential for treating AD. |
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| Keywords: | atopic dermatitis immunoglobulin E Lactobacillus rhamnosus tyndallization |
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