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Low shear stress induces vascular eNOS uncoupling via autophagy-mediated eNOS phosphorylation
Authors:Jun-Xia Zhang  Xin-Liang Qu  Peng Chu  Du-Jiang Xie  Lin-Lin Zhu  Yue-Lin Chao  Li Li  Jun-Jie Zhang  Shao-Liang Chen
Affiliation:1. Department of Cardiology, Nanjing First Hospital, Nanjing Medical University, 210006, Nanjing, China;2. Department of Cardiology, Guangzhou Red Cross Hospital, Jinan University, 510020, Guangzhou, China
Abstract:Uncoupled endothelial nitric oxide synthase (eNOS) produces O2/><sup>?</sup> instead of nitric oxide (NO). Earlier, we reported rapamycin, an autophagy inducer and inhibitor of cellular proliferation, attenuated low shear stress (SS) induced O<sub>2</sub><img style=
Keywords:Autophagic flux  Low shear stress  Endothelial cells  Endothelial nitric oxide synthase uncoupling
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