Negative regulators of growth. |
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Authors: | J Massagué R A Weinberg |
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Institution: | Howard Hughes Medical Institute, New York, New York. |
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Abstract: | The proliferation of cells is regulated by countervailing positively- and negatively-acting signaling networks. The anti-proliferative signals, the study of which has been much neglected until recently, are often conveyed by growth-inhibitory peptides. Elements that mediate the cellular response to growth inhibitors are encoded by tumor suppressor genes that if lost may lead to the runaway growth of the cancer cell. |
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