Nogo-A-specific antibody treatment enhances sprouting and functional recovery after cervical lesion in adult primates |
| |
| Authors: | Freund Patrick Schmidlin Eric Wannier Thierry Bloch Jocelyne Mir Anis Schwab Martin E Rouiller Eric M |
| |
| Affiliation: | Unit of Physiology and Program in Neurosciences, Department of Medicine, Faculty of Sciences, University of Fribourg, Chemin du Musée 5, CH-1700 Fribourg, Switzerland. |
| |
| Abstract: | In rodents, after spinal lesion, neutralizing the neurite growth inhibitor Nogo-A promotes axonal sprouting and functional recovery. To evaluate this treatment in primates, 12 monkeys were subjected to cervical lesion. Recovery of manual dexterity and sprouting of corticospinal axons were enhanced in monkeys treated with Nogo-A-specific antibody as compared to monkeys treated with control antibody. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
