Hydrophobic grafted and cross-linked starch nanoparticles for drug delivery |
| |
Authors: | C K Simi T Emilia Abraham |
| |
Institution: | (1) Chemical Sciences and Technology Division, Regional Research Laboratory (CSIR), Thiruvananthapuram, India |
| |
Abstract: | The synthesis of modified hydrophobic starch nanoparticles using long chain fatty acids was accomplished. Grafting of fatty
acid on the starch was done using potassium persulphate as catalyst and the formation of graft polymer was confirmed by FTIR
spectra. The thermal properties of the native and grafted starch were investigated using simultaneous TG-DTA and DSC. The
graft polymerization was found to be depending on the temperature and the duration of the reaction. The modified starch nanoparticles
were cross-linked with sodium tripoly phosphate for better stabilization. Morphology of the grafted starch nanoparticles was
studied by SEM and AFM. Drug-loading and the controlled release of the drug from the nanoparticles was studied using indomethacin
as model drug. |
| |
Keywords: | Chemical modification Grafting Cross-linking Nanoparticle Controlled drug release |
本文献已被 PubMed SpringerLink 等数据库收录! |