Triamcinolone acetonide inhibits lymphocyte differentiation in B cells decorated with artificial antigen receptors |
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| Authors: | D A Roess M E Zschokke J S Peacock B G Barisas |
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| Affiliation: | Department of Physiology, Colorado State University, Ft. Collins 80523. |
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| Abstract: | We examined the effects of triamcinolone acetonide (TA) on T cell independent antigen-induced differentiation of human B cells. Purified human B cells artificially decorated with palmitate-conjugated monoclonal IgA antibody specific for 2,4-dinitrophenyl differentiated polyclonally when challenged with optimum concentrations of dinitrophenyl-derivatized polymerized flagellin. This B cell response was reduced by the synthetic corticosteroid TA at a concentration of 10(-6) M. This suggests that TA can inhibit in vitro B lymphocyte differentiation independent of T cells. |
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