Artificial ladder-shaped polyethers that inhibit maitotoxin-induced Ca2+ influx in rat glioma C6 cells |
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| Authors: | Oishi Tohru Konoki Keiichi Tamate Rie Torikai Kohei Hasegawa Futoshi Matsumori Nobuaki Murata Michio |
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| Institution: | Department of Chemistry, Faculty and Graduate School of Sciences, Kyushu University, Higashi-ku, Fukuoka, Japan. oishi@chem.kyushu-univ.jp |
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| Abstract: | Maitotoxin (MTX) is a ladder-shaped polyether produced by the epiphytic dinoflagellate Gambierdiscus toxicus. It is known to elicit potent toxicity against mammals and induce influx of Ca(2+) into cells. An artificial ladder-shaped polyether possessing a 6/7/6/6/7/6/6 heptacyclic ring system, which was designed for elucidating interactions with transmembrane proteins, was found to be the most potent inhibitor against MTX-induced Ca(2+) influx that has ever been reported. |
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