Facile cleavage of RNA via phosphodiester linkage fission by Co(III) complex. |
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| Authors: | Y Matsumoto K Yonezawa M Komiyama |
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| Affiliation: | Institute of Materials Science, University of Tsukuba, Ibaraki, Japan. |
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| Abstract: | Adenylyl (3'-5')adenosine (ApA) is effectively cleaved to two adenosine molecules by [Co(trien)(H2O)2]3+ complex (trien: triethylenetetramine). The complex (0.20 M) accelerates the cleavage by 10(5) fold, decreasing half-life of ApA from 4000 years to 9.3 days. The reaction involves general base catalysis by the hydroxide ion bound to the Co(III) ion for the formation of adenosine 2',3'-cyclic phosphate (A greater than p), followed by the prompt cleavage of the intermediate to adenosine. |
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