Structure of dog and rabbit precursors of atrial natriuretic polypeptides deduced from nucleotide sequence of cloned cDNA |
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| Authors: | S Oikawa M Imai C Inuzuka Y Tawaragi H Nakazato H Matsuo |
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| Institution: | 1. Suntory Institute for Biomedical Research, Shimamoto, Mishima, Osaka 618, Japan;2. Department of Biochemistry, Miyazaki Medical College, Kiyotake, Miyazaki 889-16, Japan;1. Department of Clinical Medicine, Aarhus University, Aarhus, Denmark;2. Department of Intensive Care and Anesthesiology, Aarhus University Hospital, Aarhus, Denmark;3. Research Center for Emergency Medicine, Department of Clinical Medicine, Aarhus University and Aarhus University Hospital, Aarhus, Denmark;4. Prehospital Emergency Medical Services, Central Denmark Region, Denmark;5. Department of Anesthesiology and Intensive Care Medicine, Randers Regional Hospital, Randers, Denmark;1. Agnes Ginges Centre for Molecular Cardiology at Centenary Institute, The University of Sydney, Sydney, Australia;2. Faculty of Medicine and Health, The University of Sydney, Sidney, Australia;3. Department of Cardiology, Royal Prince Alfred Hospital, Sydney, Australia;1. Institute of Public Health and Clinical Nutrition, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland;2. Institute of Biomedicine, Physiology, University of Eastern Finland, Kuopio, Finland;3. Institute of Clinical medicine, Internal Medicine, Kuopio University Hospital, Kuopio, Finland;1. Department of Medicine, McMaster University, Hamilton, Ontario, Canada;2. Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada;3. Thrombosis and Atherosclerosis Research Institute, McMaster University, Hamilton, Ontario, Canada |
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| Abstract: | The structure of precursors of dog and rabbit atrial natriuretic polypeptides was determined by nucleotide sequence analysis of cloned cDNA of mRNA encoding the peptides. The dog and rabbit precursors are 149 and 153 residues long having 23- and 25-residue putative signal peptides at their N-termini respectively. The 28-residue peptide with identical sequence to that of human, which has potent natriuretic activity, is located at the C-terminus of the dog precursor. The 28-residue peptide of identical sequence to that of mouse/rat is located at C-terminus of rabbit precursor followed by additional Arg-Arg sequence which is also found in rat/mouse precursors and is apparently removed during processing. |
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