Muscle reinnervation and IGF-I synthesis are affected by exposure to heparin: an effect partially antagonized by anti-growth hormone-releasing hormone |
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Authors: | Madaschi Laura Di Giulio Anna Maria Gorio Alfredo |
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Institution: | (1) Dept. of Medicine, Surgery and Dentistry, Polo H. San Paolo, Pharmacological Laboratories, Via A. Di Rudinì 8, 20142 Milano Milano, Italy |
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Abstract: | Sciatic nerve crush was performed in 2-day-old rats, then reinnervation of the extensor digitorum longus muscle, motor neuron survival, and muscle IGF-I production were monitored. In saline-treated rats, the extent of reinnervation was around 50% and the number of EDL reinnervating motor neurons was significantly reduced. In heparin-treated rats the extent of muscle reinnervation, the recovery of nerve-evoked muscle twitch tension, and the number of motor neurons reinnervating the extensor digitorum longus muscle were greatly enhanced compared to saline-treated rats. In addition, treatment with heparin increased markedly insulin-like growth factor-I levels in denervated muscles. The concomitant exposure to anti-growth hormone releasing hormone partially abolished the stimulatory action of heparin on muscle reinnervation and prevented the increase of insulin-like growth factor-I muscle levels. |
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Keywords: | Glycosaminoglycans IGF-I heparin muscle reinnervation anti-GHRH peripheral nerve lesion |
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