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Studies on the synthesis and the antimicrobial and antioxidant activities of a novel class of fluorescein-based glycosides |
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| Authors: | Rajasekar Mani Jegadeesh Raman Raaman Nanjian Mohan Das Thangamuthu |
| Affiliation: | aDepartment of Organic Chemistry, University of Madras, Guindy Campus, Chennai 600 025, India;bDepartment of Botany, CAS, University of Madras, Guindy Campus, Chennai 600 025, India |
| Abstract: | Facile glycosylation of a fluorescein diol derivative with per-O-acetyl/benzoyl sugar derivatives using BF3·Et2O catalyst resulted in the formation of the expected glycosides in 54–66% yield. The biological screening of the glycosides against different microbes shows good inhibitory activity. The antioxidant activity of the fluorescein-based glycosides shows remarkable inhibition (IC50 ∼80%). |
| Keywords: | Partially protected sugars Glycosides Fluorescein diol Antimicrobial activity Antioxidant activity |
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