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Synthesis of lipid II phosphonate analogues |
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| Authors: | Borbás Anikó Herczegh Pál |
| Affiliation: | aResearch Group for Carbohydrates of the Hungarian Academy of Sciences, University of Debrecen, PO Box 94, H-4010 Debrecen, Hungary;bDepartment of Pharmaceutical Chemistry, Center of Medical and Health Sciences, University of Debrecen, PO Box 70, H-4010 Debrecen, Hungary |
| Abstract: | Simple analogues of lipid II were synthesized from 3,4,6-tri-O-acetyl-2-acetamido-2-deoxy-1-thio-β-d-glucopyranose using conjugate addition onto ethylidene bisphosphonate and subsequent Wadsworth–Horner–Emmons reaction with long chain aliphatic aldehydes. |
| Keywords: | Lipid II analogues Conjugate addition Wadsworth&ndash Horner&ndash Emmons reaction |
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