Synthesis and antibacterial evaluation of a series of oligorhamnoside derivatives |
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| Authors: | Ding Ning Zhang Zaihong Zhang Wei Chun Yuexing Wang Peng Qi Huimin Wang Shan Li Yingxia |
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| Institution: | aDepartment of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai 201203, China;bSchool of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China;cInstitute of Clinical Pharmacology, The First Hospital, Peking University, China |
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| Abstract: | A series of novel oligorhamnoside derivatives (1–10) and naturally occurring cleistrioside-5 were synthesized and evaluated for their in vitro antibacterial activities. Among them, dirhamnoside derivative 7 and cleistrioside-5 displayed similar antibacterial profiles and exhibited moderate to good inhibitory activities on bacterial growth against a panel of Gram-positive bacteria (MICs ? 4–32 μg/mL). The results revealed that these two compounds showed selectivity towards bacterial species strictly, without being affected by the antibiotic-resistant/susceptible properties of one species, which suggested that they might have the potential to avoid antibiotic cross-resistance. In addition, the preliminary SARs of this type of oligorhamnoside derivatives on the antibacterial activities were determined. |
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| Keywords: | Oligorhamnoside Antibacterial activities Cleistrioside Cleistetrosides Antibiotic-resistant |
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