Oral Microbiota Distinguishes Acute Lymphoblastic Leukemia Pediatric Hosts from Healthy Populations |
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| Authors: | Yan Wang Jing Xue Xuedong Zhou Meng You Qin Du Xue Yang Jingzhi He Jing Zou Lei Cheng Mingyun Li Yuqing Li Yiping Zhu Jiyao Li Wenyuan Shi Xin Xu |
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| Institution: | 1. State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.; 2. Department of Pediatric Hematology and Oncology, West China Second University Hospital, Sichuan University, Chengdu, China.; 3. Department of Pediatric Dentistry, West China Hospital of Stomatology, Sichuan University, Chengdu, China.; 4. UCLA School of Dentistry, Los Angeles, California, United States of America.; Instutite of Agrochemistry and Food Technology, Spain, |
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| Abstract: | In leukemia, oral manifestations indicate aberrations in oral microbiota. Microbiota structure is determined by both host and environmental factors. In human hosts, how health status shapes the composition of oral microbiota is largely unknown. Taking advantage of advances in high-throughput sequencing, we compared the composition of supragingival plaque microbiota of acute lymphoblastic leukemia (ALL) pediatric patients with healthy controls. The oral microbiota of leukemia patients had lower richness and less diversity compared to healthy controls. Microbial samples clustered into two major groups, one of ALL patients and another of healthy children, with different structure and composition. Abundance changes of certain taxa including the Phylum Firmicutes, the Class Bacilli, the Order Lactobacillales, the Family Aerococcaceae and Carnobacteriaceae, as well as the Genus Abiotrophia and Granulicatella were associated with leukemia status. ALL patients demonstrated a structural imbalance of the oral microbiota, characterized by reduced diversity and abundance alterations, possibly involved in systemic infections, indicating the importance of immune status in shaping the structure of oral microbiota. |
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