Distinct Facial Processing Related Negative Cognitive Bias in First-Episode and Recurrent Major Depression: Evidence from the N170 ERP Component |
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| Authors: | Jiu Chen Wentao Ma Yan Zhang Xingqu Wu Dunhong Wei Guangxiong Liu Zihe Deng Laiqi Yang Zhijun Zhang |
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| Affiliation: | 1Neurologic Department of Affiliated ZhongDa Hospital, Neuropsychiatric Institute and Medical School of Southeast University, Nanjing, Jiangsu Province, China;2Center for Mental Disease Control and Prevention, Third Hospital of the People’s Liberation Army, Baoji, Shaanxi Province, China;Cardiff University, United Kingdom |
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| Abstract: | BackgroundStates of depression are associated with increased sensitivity to negative events. For this novel study, we have assessed the relationship between the number of depressive episodes and the dysfunctional processing of emotional facial expressions.Conclusion/SignificanceThese results provide new evidence that having more recurrent depressive episodes and serious depressive states are likely to aggravate the already abnormal processing of emotional facial expressions in patients with depression. Moreover, it further suggests that the impaired processing as indexed by N170 amplitude for positive face identification may be a potentially useful biomarker for predicting propagation of depression while N170 amplitude for negative face identification could be a potential biomarker for depression recurrence. |
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