Synthesis and DNA-cleavage properties of metal complexes of 1,4,7,10-tetraazacyclododecane (cyclen) functionalized with a pendant benzocrown ether |
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| Authors: | Tan Xin-Yu Zhang Ji Huang Yu Zhang Yu Zhou Li-Hong Jiang Ning Lin Hong-Hui Wang Na Xia Chuan-Qin Yu Xiao-Qi |
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| Affiliation: | Department of Chemistry, Key Laboratory of Green Chemistry and Technology, (Ministry of Education), Sichuan University, Chengdu 610064, PR China. |
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| Abstract: | The synthesis and DNA-cleavage properties of a series of novel mononuclear Zn(II), Cu(II), and Co(II) complexes 2 of a crown-ether-functionalized cyclen ligand is described. The Cu complex 2b displayed the highest catalytic activity towards pUC 19 DNA. The effects of reaction time, complex concentration, and pH were investigated, showing that 2b readily and efficiently converts supercoiled (type I ) plasmid DNA to nicked (type II) DNA under physiological conditions (37 degrees, pH 7.4). |
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| Keywords: | 1,4,7,10‐Tetraazacyclododecane Cyclen Copper complexes DNA Crown ethers |
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