|
|||||
|
|
Codon-specific interaction of uncharged transfer-RNA with eukaryotic ribosomes. |
|
| Authors: | M J Murchie D P Leader |
| Abstract: | Rat liver ribosomes bound [32P]tRNAPhe in both a codon-dependent and codon-independent manner. The codon-dependent binding was studied further by utilising the ability of the unchanged tRNAPhe to inhibit the poly(U)-directed binding of [3H]Phe-tRNA to ribosomes. At least part of the codon-dependent binding of uncharged tRNA appears to be to the ribosomal A-site. |
| Keywords: | |