The human vocal cord surface |
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| Authors: | Prof Dr Bernhard Tillmann Ilsabe Pietzsch-Rohrschneider Hans L Huenges |
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| Institution: | (1) Department of Anatomy, University of Munich, Munich, Germany;(2) Department of Anatomy, University of Kiel, Kiel, Germany;(3) Anatomisches Institut der Universität Kiel, Neue Universität, Eingang F1/F3, D-2300 Kiel, Federal Republic of Germany |
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| Abstract: | Summary The effect of phenylthiourea (PTU) on the pigment epithelium and the photoreceptor cells in the developing retina of Haplochromis burtoni was studied by electron microscopy. In the retinal pigment epithelium of 6-day old embryos, both types of melanin granule (spindle-shaped and rod-shaped) are already found. PTU inhibits the biosynthesis of melanin but does not influence the formation of premelanosomes so that in PTU-treated embryos there are no melanosomes, but an abundance of premelanosomes. The structure of the premelanosomes is described. It differs completely from that of all other vertebrates. Other changes: an increase in polysomes, retarded development of the inner segment of the photoreceptor cells and enlargement of the intercellular space between the inner and outer leaflet of the retina, may be due to a toxic effect of PTU.This investigation was supported by grants of the Deutsche Forschungsgemeinschaft |
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| Keywords: | Embryonic retinal pigment epithelium Premelanosomes Photoreceptor cells Phenylthiourea Haplochromis burtoni |
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