|
|||||
|
|
| 骨髓间充质干细胞移植治疗大鼠肝损伤的实验研究 | |
| 引用本文： | 卢兴浩,裴雪莲,肖智伟,郑丽华,慕晓玲. 骨髓间充质干细胞移植治疗大鼠肝损伤的实验研究[J]. 现代生物医学进展, 2010, 10(3) |
| 作者姓名： | 卢兴浩 裴雪莲 肖智伟 郑丽华 慕晓玲 |
| 作者单位： | 1. 蚌埠医学院人体解剖学教研室,安徽,蚌埠,233000 2. 石河子大学医学院新疆地方与民族高发病教育部重点实验室/组胚教研室 新疆 石河子 832002 3. 石河子大学医学院,新疆,石河子,832002 |
| 摘 要： | 目的:了解肝损伤大鼠在输注骨髓间充质干细胞后肝功能生化指标和肝脏组织病理变化情况,为临床应用提供实验依据。方法:将大鼠随机分为正常组和造模组。造模组采用腹腔注射四氯化碳的方法构建,然后将造模组随机分为干细胞移植治疗组、模型对照组。干细胞移植组经门静脉输注标记的骨髓间充质干细胞。3周后处死大鼠。然后检测大鼠肝功能、肝脏病理改变分析干细胞移植治疗肝损伤效果。结果:干细胞移植治疗3周后,大鼠的肝脏与对照组比较,明显恢复,但是并没有恢复到正常水平。结论:骨髓间充质干细胞对肝损伤的大鼠有治疗作用。 |
| 关 键 词： | 骨髓间充质干细胞 移植 肝损伤 大鼠 |
Experimental Study on Bone Marrow Mesenchymal Stem Cell Transplantation for Chronic Liver Injury in Rats |
|
| LU Xing-hao,PEI Xue-lian,XIAO hi-we,ZHENG Li-hua,MU Xiao-ling. Experimental Study on Bone Marrow Mesenchymal Stem Cell Transplantation for Chronic Liver Injury in Rats[J]. Progress in Modern Biomedicine, 2010, 10(3) | |
| Authors: | LU Xing-hao PEI Xue-lian XIAO hi-we ZHENG Li-hua MU Xiao-ling |
| Affiliation: | LU Xing-hao1,PEI Xue-lian2,XIAO Zhi-wei3,ZHENG Li-hua3,MU Xiao-ling2 (1 Department of Human Anatomy,Bengbu Medical College,Bengbu 233000 China,2 Ministry of Education Key Laboratory of Xinjiang Endemic , Ethnic Disease /Department of Histology , Embryology,College of Medicine,Shihezi University,Shihezi 832002 China,3 Medical College of Shihezi University,Xinjiang Shihezi 832002 China) |
| Abstract: | Objective:To understand biochemical indicators of liver function and liver histopathological changes by infusion of bone marrow-derived mesenchymal stem cells in rats, to provide experimental basis for clinical applications.Method:The rats were randomly divided into normal group and model group. To Built model group,we inject carbon tetrachloride by intraperitoneal, and then randomly divided into the treatment group, model control group . Stem cell transplantation group tag via portal vein infusion of bone ... |
| Keywords: | Bone marrow mesenchymal stem cells Transplantation Liver injury Rats |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |