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Leucine Signals to mTORC1 via Its Metabolite Acetyl-Coenzyme A
Authors:Sung Min Son  So Jung Park  Huikyong Lee  Farah Siddiqi  Jong Eun Lee  Fiona M Menzies  David C Rubinsztein
Institution:1. Department of Medical Genetics, Cambridge Institute for Medical Research (CIMR), University of Cambridge, Cambridge, UK;2. UK Dementia Research Institute, Cambridge Institute for Medical Research (CIMR), University of Cambridge, Cambridge, UK;3. Department of Anatomy, Bk21 Plus Project for Medical Sciences and Brain Research Institute, Yonsei University College of Medicine, Seoul 03722, Republic of Korea
Abstract:
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  • Keywords:mTOR  acetyl-CoA  leucine  autophagy  starvation  amino acid sensing  Raptor
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