Reconstitution of a partially purified endplate acetylcholine receptor preparation in lipid bilayer membranes |
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| Authors: | G. Kemp J.O. Dolly E.A. Barnard C.E. Wenner |
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| Affiliation: | 1. New York State Department of Health, Roswell Park Memorial Institute, Buffalo, New York 14203 USA;2. Department of Biochemistry, State University of New York at Buffalo, Buffalo, New York 14214 USA |
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| Abstract: | Incorporation of a fraction isolated from rat diaphragm muscle that contained the specific endplate cholinergic receptor into phospholipid bilayer membranes resulted in the production of an acetylcholine-stimulated conductance increment of large magnitude. The acetylcholine-stimulated conductance shows several characteristics of the post-synaptic excitable system. |
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