The influence of A and C mutations on the initiation of plasmid DNA replication |
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Authors: | Werner Goebel |
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Affiliation: | Institut für Mikrobiologie und Molekularbiologie Universität Hohenheim, D 7000 Stuttgart 70, Germany |
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Abstract: | The dependence of the replication of several plasmids on the chromosome-determined initiation products, A and C, has been studied. The initiation of the replication of E1 DNA requires the chromosomal A product. In contrast two de-repressed transfer factors ( and 152) seem to determine a corresponding plasmid-specific factor. The C-product is necessary for the ordered initation of all plasmids studied. The addition of low concentrations of chloramphenicol leads to a relaxed replication of E1 DNA at the restrictive temperature in A-mutants, but not in C-mutants. |
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