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CORRELATIONAL SELECTION ON PRO‐ AND ANTI‐INFLAMMATORY EFFECTORS
Authors:Romain Guerreiro  Anne A Besson  Jérôme Bellenger  Kévin Ragot  Gérard Lizard  Bruno Faivre  Gabriele Sorci
Institution:1. Biogéosciences, CNRS UMR 6282, Université de Bourgogne, 6 Bd Gabriel, 21000 Dijon, France;2. E‐mail: romain.guerreiro@u‐bourgogne.fr;3. Physiopathologie des dyslipidémies, INSERM UMR 866, Université de Bourgogne, 21000 Dijon, France;4. Biochimie Métabolique et Nutritionnelle, INSERM UMR 866, Université de Bourgogne, 21000 Dijon, France
Abstract:Parasites impose a permanent threat for hosts. As a consequence, immune defenses are important for host fitness. However, the immune response can also produce self‐damage and impair host fitness if not properly regulated. Effectors that up‐ and downregulate the immune response should, therefore, evolve in concert, and be under the action of correlational selection. To address this issue, we assessed the shape of the selection operating on pro‐ and anti‐inflammatory effectors following an inflammatory challenge in laboratory mice. We found that selection acts on the combination of these two traits as individuals that produced large amount of pro‐inflammatory cytokines could achieve relatively high fitness (survival) only if also producing a large amount of anti‐inflammatory effectors. To our knowledge, this is the first study providing evidence for correlational selection on immunity.
Keywords:Cytokines  Darwinian medicine  evolutionary immunology  IL‐6  IL‐10  immunopathology  inflammation  survival
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