首页 | 本学科首页   官方微博 | 高级检索  
     


The Itaconate Pathway Is a Central Regulatory Node Linking Innate Immune Tolerance and Trained Immunity
Authors:Jorge Domínguez-Andrés  Boris Novakovic  Yang Li  Brendon P. Scicluna  Mark S. Gresnigt  Rob J.W. Arts  Marije Oosting  Simone J.C.F.M. Moorlag  Laszlo A. Groh  Jelle Zwaag  Rebecca M. Koch  Rob ter Horst  Leo A.B. Joosten  Cisca Wijmenga  Alessandro Michelucci  Tom van der Poll  Matthijs Kox  Peter Pickkers  Mihai G. Netea
Affiliation:1. Department of Internal Medicine (463) and Radboud Center for Infectious Diseases (RCI), Radboud University Nijmegen Medical Centre, Geert Grooteplein 8, Nijmegen 6500 HB, the Netherlands;2. Department of Molecular Biology, Faculty of Science, Radboud University, Nijmegen 6525 GA, the Netherlands;3. Department of Genetics, University Medical Center Groningen, Groningen, the Netherlands;4. Center of Experimental & Molecular Medicine, Division of Infectious Diseases, Amsterdam Medical Center, University of Amsterdam, Amsterdam, the Netherlands;5. Department of Intensive Care and Radboud Center for Infectious diseases (RCI), Radboud University Nijmegen Medical Centre, Geert Grooteplein 8, Nijmegen 6500 HB, the Netherlands;6. NORLUX Neuro-Oncology Laboratory, Department of Oncology, Luxembourg Institute of Health, Luxembourg, Luxembourg;7. Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-Belval, Luxembourg;8. Department for Genomics & Immunoregulation, Life and Medical Sciences Institute (LIMES), University of Bonn, Bonn, Germany;9. Human Genomics Laboratory, Craiova University of Medicine and Pharmacy, Craiova, Romania;10. Department of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute, Jena, Germany
Abstract:
/><ol class=
  • Download high-res image (158KB)
  • Download full-size image
  • Keywords:sepsis  tolerance  trained immunity  itaconate  monocytes  epigenetics  succinate  metabolism  LPS  immunoparalysis
    本文献已被 ScienceDirect 等数据库收录!
    设为首页 | 免责声明 | 关于勤云 | 加入收藏

    Copyright©北京勤云科技发展有限公司  京ICP备09084417号