Freeze-etch electron microscopy of erythrocytes,Acholeplasma laidlawii cells and liposomal membranes after the action of filipin and amphotericin B |
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| Authors: | AJ Verkleij B de Kruijff WF Gerritsen RA Demel LLM van Deenen PHJ Ververgaert |
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| Institution: | 1. Laboratory of Biochemistry, State University of Utrecht,The Netherlands;2. Biological Ultrastructural Research Unit, Utrecht The Netherlands |
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| Abstract: | Freeze-etch electron microscopy demonstrated that filipin induces the formation of aggregates 150–250Åin diameter, in the membranes of rat erythrocytes, in cholesterol-containing membranes ofAcholeplasma laidlawii cells and in egg lecithin-cholesterol liposomes. No change in fracture faces was observed when cholesterol was absent in the membranes ofA. laidlawii, and lecithin liposomes.Amphotericin B does not visibly affect the freeze-etch morphology of erythrocytes, cholesterol-containingA. laidlawii cells and lecithin-cholesterol liposomes. |
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