Plasma extracellular superoxide dismutase activity in healthy pregnant women is not influenced by zinc supplementation |
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Authors: | Tsunenobu Tamura Katherine L Olin Robert L Goldenberg Kelley E Johnston Mary B DuBard Carl L Keen |
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Institution: | (1) Department of Nutrition Sciences, University of Alabama at Birmingham, 35294 Birmingham, AL;(2) Department of Obstetrics and Gynecology, University of Alabama at Birmingham, 35294 Birmingham, AL;(3) Department of Nutrition, University of California, 95616 Davis, CA |
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Abstract: | We hypothesized that plasma extracellular superoxide dismutase (EC-SOD) activity reflects the zinc nutriture of healthy pregnant
women. Sixty-three women were selected from 580 African-American women who participated in a clinical trial to evaluate the
effect of prenatal zinc supplementation on pregnancy outcome. Half of the women received zinc (25 mg/d) and the other half
was given a placebo from about 19 wk gestation to delivery. In the trial, a positive effect of zinc supplementation on birthweight
was observed, indicating that the population as a whole had suboptimal zinc nutriture. Using plasma samples obtained during
the trial, EC-SOD activities were measured and the values were compared with plasma zinc concentrations and plasma alkaline
phosphatase activities. Plasma EC-SOD activities in our subjects were lower than previously published values for healthy adults
in Korea. Although plasma EC-SOD activity may reflect severe zinc deficiency, it is not a sensitive marker for marginal deficiency
status. Plasma EC-SOD activities did not prove to be a better indicator of zinc nutriture of pregnant women than either plasma
zinc or plasma alkaline phosphatase activities. |
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Keywords: | Extracellular superoxide dismutase pregnancy zinc supplementation alkaline phosphatase copper human |
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