A new XmnI polymorphism in the regulatory region of the corticotropin releasing hormone gene |
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| Authors: | Christoph G O Baerwald Gabriel S Panayi J S Lanchbury |
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| Institution: | (1) Molecular Immunogenetics and Rheumatology Units, United Medical and Dental School, Guy's Campus, SE1 9RT London, UK;(2) Division of Medicine, UMDS, Molecular Immunogenetics Unit, 4th Floor, Hunt's House, Guy's Hospital, SE1 9RT London, UK |
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| Abstract: | We describe the first polymorphism in the 5 flanking region of the corticotropin releasing hormone (CRH) gene. DNA sequencing analysis identified a T  G base substitution in the 5 flanking region of the gene. This substitution leads to the loss of anXmnI site at position 255 of the Genbank entry X67661. The frequency analysis in 32 Caucasians revealed that it is a rare polymorphism, with only three observed heterozygous individiuals for this polymorphism. |
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