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Conservation and divergence of ADAM family proteins in the <Emphasis Type="Italic">Xenopus</Emphasis> genome |
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| Authors: | Shuo Wei Charles A Whittaker Guofeng Xu Lance C Bridges Anoop Shah Judith M White Douglas W DeSimone |
| Institution: | (1) Department of Cell Biology and the Morphogenesis and Regenerative Medicine Institute, University of Virginia, 22908 Charlottesville, VA, USA;(2) David H. Koch Institute for Integrative Cancer Research at Massachusetts Institute of Technology, 02139 Cambridge, MA, USA;(3) Department of Chemistry, University of Central Arkansas, 72035 Conway, AR, USA |
| Abstract: | BackgroundMembers of the disintegrin metalloproteinase (ADAM) family play important roles in cellular and developmental processes through their functions as proteases and/or binding partners for other proteins. The amphibian Xenopus has long been used as a model for early vertebrate development, but genome-wide analyses for large gene families were not possible until the recent completion of the X. tropicalis genome sequence and the availability of large scale expression sequence tag (EST) databases. In this study we carried out a systematic analysis of the X. tropicalis genome and uncovered several interesting features of ADAM genes in this species. |
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