Rhomboid homologs in mycobacteria: insights from phylogeny and genomic analysis |
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Authors: | David P Kateete Moses Okee Fred A Katabazi Alfred Okeng Jeniffer Asiimwe Henry W Boom Kathleen D Eisenach Moses L Joloba |
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Institution: | 1.Department of Medical Microbiology,School of Biomedical Sciences, Makerere University College of Health Sciences,Kampala,Uganda;2.Department of Veterinary Parasitology & Microbiology,Faculty of Veterinary Medicine, Makerere University,Kampala,Uganda;3.Case Western Reserve University,Cleveland,USA;4.Department of Pathology,University of Arkansas for Medical Sciences,Little Rock,USA |
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Abstract: | Background Rhomboids are ubiquitous proteins with diverse functions in all life kingdoms, and are emerging as important factors in the
biology of some pathogenic apicomplexa and Providencia stuartii. Although prokaryotic genomes contain one rhomboid, actinobacteria can have two or more copies whose sequences have not been
analyzed for the presence putative rhomboid catalytic signatures. We report detailed phylogenetic and genomic analyses devoted
to prokaryotic rhomboids of an important genus, Mycobacterium. |
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