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Rhomboid homologs in mycobacteria: insights from phylogeny and genomic analysis
Authors:David P Kateete  Moses Okee  Fred A Katabazi  Alfred Okeng  Jeniffer Asiimwe  Henry W Boom  Kathleen D Eisenach  Moses L Joloba
Institution:1.Department of Medical Microbiology,School of Biomedical Sciences, Makerere University College of Health Sciences,Kampala,Uganda;2.Department of Veterinary Parasitology & Microbiology,Faculty of Veterinary Medicine, Makerere University,Kampala,Uganda;3.Case Western Reserve University,Cleveland,USA;4.Department of Pathology,University of Arkansas for Medical Sciences,Little Rock,USA
Abstract:

Background  

Rhomboids are ubiquitous proteins with diverse functions in all life kingdoms, and are emerging as important factors in the biology of some pathogenic apicomplexa and Providencia stuartii. Although prokaryotic genomes contain one rhomboid, actinobacteria can have two or more copies whose sequences have not been analyzed for the presence putative rhomboid catalytic signatures. We report detailed phylogenetic and genomic analyses devoted to prokaryotic rhomboids of an important genus, Mycobacterium.
Keywords:
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