Melt-in-Mouth Pellets of Fexofenadine Hydrochloride Using Crospovidone as an Extrusion–Spheronisation Aid |
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Authors: | Satishkumar P Jain Dharmini C Mehta Sejal P Shah Pirthi Pal Singh Purnima D Amin |
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Institution: | (1) Department Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Matunga, Mumbai, 400019, India; |
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Abstract: | Microcrystalline cellulose (MCC) is well established as an extrusion spheronisation aid for the preparation of pellets. Crospovidone (Polyplasdone® XL-10) is compared with microcrystalline cellulose for the preparation of melt-in-mouth pellets. Taste-masked fexofenadine hydrochloride was incorporated in the melt-in-mouth formulation. Crospovidone was found to be well suited as extrusion–spheronisation aid for the preparation of melt-in-mouth pellets. The great advantage of crospovidone is, however, the disintegrating properties of the pellets after only a short time of exposure to liquid. Crospovidone was successfully employed as an extrusion–spheronisation aid to produce melt-in-mouth pellets obviating the need of a traditional extrusion–spheronisation aid, MCC. Dual properties of Crospovidone were explored viz. as an extrusion–spheronisation aid and a disintegrant. |
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