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1-Aryl-3,4-dihydro-1H-quinolin-2-one derivatives, novel and selective norepinephrine reuptake inhibitors |
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| Authors: | Beadle Christopher D Boot John Camp Nicholas P Dezutter Nancy Findlay Jeremy Hayhurst Lorna Masters John J Penariol Roberta Walter Magnus W |
| Institution: | Eli Lilly and Company Ltd, Lilly Research Centre, Erl Wood Manor, Windlesham, Surrey, GU20 6PH, UK. |
| Abstract: | A novel series of 1-aryl-3,4-dihydro-1H-quinolin-2-ones have been discovered as potent and selective norepinephrine reuptake inhibitors. Efficient synthetic routes have been developed which allow for the multi-gram preparation of both final targets and advanced intermediates for SAR expansion. |
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