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Antiviral activity of the volatile oils of Melissa officinalis L. against Herpes simplex virus type-2 |
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| Authors: | A Allahverdiyev N Duran M Ozguven S Koltas |
| Institution: | aTropical Diseases Center, Faculty of Medicine, Cukurova University, Adana, Turkey bDepartment of Microbiology, Faculty of Medicine, Mustafa Kemal University, Antakya, Turkey cDepartment of Field Crops, Faculty of Agriculture, Cukurova University, Adana, Turkey dDepartment of Parasitology, Faculty of Medicine, Cukurova University, Adana, Turkey |
| Abstract: | Melissa officinalis L. (Lamiaceae) has been used in a variety of practical applications in medical science. Our objective in the current study was to determine the effects of the volatile oil components of M. officinalis on Herpes simplex virus type 2 (HSV-2) replication in HEp-2 cells. Four different concentrations (25, 50, 100, 150 and 200 μg/ml) of volatile oils were examined. Experiments were carried out using HEp-2 cells. M. officinalis volatile oil was found to be non-toxic to HEp-2 cells up to a concentration of 100 μg/ml. It was, however, found to be slightly toxic at a concentration over of 100 μg/ml. The antiviral activity of non-toxic concentrations against HSV-2 was tested. The replication of HSV-2 was inhibited, indicating that the M. officinalis L. extract contains an anti-HSV-2 substance. |
| Keywords: | Melissa officinalis L HEp-2 cells Antiviral activity TCID50 value Cytotoxicity |
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