儿童血液凝固酶阴性葡萄球菌的感染情况及耐药性分析

目的了解本院儿童血培养凝固酶阴性葡萄球菌（CNS）的感染率及其药物敏感情况，为儿科合理使用抗生素提供依据。方法对本院2006年1月至2007年12月间住院及门诊儿童血液培养的结果进行回顾性统计分析。结果在1265例儿童血培养中共检出CNS117株，其中表皮葡萄球菌41株（占35．0％），人葡萄球菌27株（占23．1％），溶血葡萄球菌21株（占18．0％），其他凝固酶阴性葡萄球菌28株（占23．9％）；耐甲氧西林凝固酶阴性葡萄球菌（MRCNS）分离率为79．5％；MRCNS药敏结果显示多重耐药。结论CNS已成为儿童血液感染的重要致病菌，MRCNS检出率高且多重耐药，万古霉素、喹宁始霉素-达福普汀、呋西地酸是治疗MRCNS感染的首选药物。

Resistance of coagulase negative staphylococcus in children's blood infection

Objective To explore the infection and medicine susceptibility of blood culture coagulase negative staphylococcus(CNS) in children,and provide evidence for use of antibiotics in pediatrics.Methods Blood cultures from in-and out-patient children from January 2006 to December 2007 were collected and a retrospective analysis on the drug resistance of the bacteria was performed. Results Total 117 strains of coagulase negative staphylococcus were isolated from 1265 blood cultures.Among 117 CNS, there were 41 S.epidermidis strains(35.0%), 27 S.hominis strains(23.1%),21 S.hemolyticus(18.0%),and 28 other kinds of Staphylococcus strains(23.9%).The isolated ratio of meticillin-resistant coagulase negative staphylococcus(MRCNS) was 79.5%(93/117).Susceptibility test showed that the MRCNS were multiple resistant.Conclusions CNS is increasingly playing a significant role in children's blood infection.The isolated ratio of MRCNS is high and shows multi-drug resistance.Vancomycin,Quinupristine-Dalfopristine and Fusidin are the first choice for MRCNS infections.