| 三萜皂苷生物合成相关糖基转移酶研究进展 |
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| 引用本文： | 周宸,巩婷,陈晶晶,陈天娇,杨金玲,朱平.三萜皂苷生物合成相关糖基转移酶研究进展[J].生物工程学报,2022,38(3):1004-1024. |
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| 作者姓名： | 周宸 巩婷 陈晶晶 陈天娇 杨金玲 朱平 |
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| 作者单位： | 中国医学科学院 北京协和医学院药物研究所 天然药物活性物质与功能国家重点实验室 国家卫生健康委员会天然药物生物合成重点实验室 & 中国医学科学院酶与天然药物生物催化重点实验室, 北京 100050 |
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| 基金项目： | 北京市自然科学基金(7212158)；国家自然科学基金(81673341)；北京协和医学院-合成生物学学科建设(201920100801) |
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| 摘 要： | 三萜皂苷具有独特的化学性质和丰富的药理活性,在医药、保健品、化妆品、食品添加剂、农业等方面被广泛应用.尿苷二磷酸(UDP)依赖的糖基转移酶(UGTs)是催化三萜皂苷生成的关键酶,对三萜皂苷的结构及其药理活性多样性的形成有重要作用.文中基于UGTs来源及受体底物结构类型对参与植物三萜皂苷生物合成的UGTs进行了综述,并展...
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| 关 键 词： | 尿苷二磷酸依赖的糖基转移酶(UGTs) 三萜皂苷 糖基化 天然产物 生物合成 |
| 收稿时间： | 2021/8/3 0:00:00 |
| 修稿时间： | 2021/9/6 0:00:00 |
The glycosyltransferases involved in triterpenoid saponin biosynthesis:a review |
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| ZHOU Chen,GONG Ting,CHEN Jingjing,CHEN Tianjiao,YANG Jinling,ZHU Ping.The glycosyltransferases involved in triterpenoid saponin biosynthesis:a review[J].Chinese Journal of Biotechnology,2022,38(3):1004-1024. |
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| Authors: | ZHOU Chen GONG Ting CHEN Jingjing CHEN Tianjiao YANG Jinling ZHU Ping |
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| Institution: | NHC Key Laboratory of Biosynthesis of Natural Products, CAMS Key Laboratory of Enzyme and Biocatalysis of Natural Drugs, State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China |
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| Abstract: | Triterpenoid saponins are widely used in medicine,health cares,cosmetics,food additives and agriculture because of their unique chemical properties and rich pharmacological activities.UDP-dependent glycosyltransferases (UGTs) are the key enzymes involved in triterpenoid saponin biosynthesis,and play important roles in the diversity of triterpenoid saponin structures and pharmacological activities.This review summarized the UGTs involved in plant triterpenoid saponin biosynthesis based on the sources of UGTs and the types of receptors.Moreover,the application of UGTs in heterologous biosynthesis of triterpenoid saponins based on synthetic biology was also discussed. |
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| Keywords: | UDP-dependent glycosyltransferase triterpenoid saponin glycosylation natural product biosynthesis |
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