Question 8: Bridging the Gap Between In Silico and In Vitro Approaches to Minimal Cells |
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Authors: | Fabio Mavelli Kepa Ruiz-Mirazo |
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Affiliation: | (1) Department of Chemistry, University of Bari, Via Orabona 4, 70125 Bari, Italy;(2) Department of Logic and Philosophy of Science / Biophysics Research Unit (CSIC-UPV/EHU), University of the Basque Country, Donostia-San Sebastián, Spain |
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Abstract: | In this short paper we argue for the relevance and value of theoretical models in the field of origins of life, but also claim that both theoreticians and experimentalists should make an effort to come together and interact more closely to obtain more fruitful and significant results. As an example, we present our own modeling approach to protocell dynamics, including some simulation results, to show that it is possible to develop computational tools that start bridging that traditional gap between theory and experiments. Presented at: International School of Complexity – 4th Course: Basic Questions on the Origins of Life; “Ettore Majorana” Foundation and Centre for Scientific Culture, Erice, Italy, 1–6 October 2006. |
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Keywords: | Protocell (vesicle) dynamics Stochastic kinetics (Gillespie method) Self-assembly Autocatalysis Osmotic crisis |
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